ЦТП ФХФ РАН
Лаборатория физиологии и биофизики клетки
Лаборатория молекулярных механизмов гемостаза
Лаборатория теоретических проблем метаболического управления и портретирования
Лаборатория функциональной морфологии гемобластозов
Лаборатория физико-химических и генетических проблем дерматологии
Лаборатория этнической фармакологической метрологии
Логин:

Пароль:

Лаборатория физиологии и биофизики клетки

Имя руководителя:

Фазоил Иноятович Атауллаханов, профессор, д.б.н., директор ЦТП ФХФ РАН
Фазоил Иноятович Атауллаханов

Контактная информация:

Центр теоретических проблем физико-химической фармакологии РАН, ул. Косыгина, 4, Москва, 119991
Телефон: 7-495-6125531
Факс: 7-495-6128870
e-mail: ataullakhanov.fazly@gmail.com

Деятельность подразделения

Математическое моделирование метаболических сетей
Теория метаболического контроля
Биофизика сложных систем
Нелинейная динамика
Пространственная динамика свертывания крови
Самоорганизация и формирование структур в делении клетки
Биотехнология и разработка новых приборов для научных исследований

Публикации

Книги

1. Пантелеев МА, Васильев СА, Синауридзе ЕИ, Воробьев АИ, Атауллаханов ФИ. Практическая коагулология. (под ред. Воробьева АИ). Москва, “Практическая медицина”, 2010, 192 стр., ISBN: 978-5-98811-165-8
2. Mathematical Modeling and Computer Simulation in Blood Coagulation./Eds. F.I. Ataullakhanov and M.A. Panteleev, Karger, Basel, 2005, 94 pages.

Статьи

1. Grishchuk EL, Ataullakhanov FI. In vitro assays to study the tracking of shortening microtubule ends and to measure associated forces. Methods Cell Biol. 2010;95:657-76.
2. Korendyaseva TK, Martinov MV, Dudchenko AM, Vitvitsky VM. Distribution of methionine between cells and incubation medium in suspension of rat hepatocytes. Amino acids. 2010;39(5):1281-9.
3. McIntosh JR, Volkov V, Ataullakhanov FI, Grishchuk EL. Tubulin depolymerization may be an ancient biological motor. J Cell Sci. 2010 Oct 15;123(Pt 20):3425-34.
4. Panteleev MA, Balandina AN, Lipets EN, Ovanesov MV, Ataullakhanov FI. Task-oriented modular decomposition of biological networks: trigger mechanism in blood coagulation. Biophys J 2010; 98(9):1751-1761
5. Shibeko AM, Lobanova ES, Panteleev MA, Ataullakhanov FI. Blood flow controls coagulation onset via the positive feedback of factor VII activation by factor Xa. BMC Systems Biology 2010; 4(1): 5.
6. Martinov MV, Vitvitsky VM, Banerjee R, Ataullakhanov FI. The logic of the hepatic methionine metabolic cycle. Biochimica et Biophysica Acta (Proteins and Proteomics) 1804(2010): 89-96.
7. Ermakova EA, Shnol EE, Panteleev MA, Butylin AA, Volpert V, Ataullakhanov FI. On propagation of excitation waves in moving media: the FitzHugh-Nagumo model. PLoS ONE. 2009; 4(2): e4454
8. Ovanesov MV, Panteleev MA, Sinauridze EI, Kireev DA, Plyushch OP, Kopylov KG, Lopatina EG, Saenko EL, Ataullakhanov FI. Mechanisms of action of recombinant activated factor VII in the context of tissue factor concentration and distribution. Blood Coagul Fibrinolysis. 2008 Dec;19(8):743-55.
9. McIntosh JR, Grishchuk EL, Morphew MK, Efremov AK, Zhudenkov K, Volkov VA, Cheeseman IM, Desai A, Mastronarde DN, Ataullakhanov FI. Fibrils connect microtubule tips with kinetochores: a mechanism to couple tubulin dynamics to chromosome motion. Cell. 2008 Oct 17;135(2):322-33.
10. Grishchuk EL, Efremov AK, Volkov VA, Spiridonov IS, Gudimchuk N, Westermann S, Drubin D, Barnes G, McIntosh JR, Ataullakhanov FI. The Dam1 ring binds microtubules strongly enough to be a processive as well as energy-efficient coupler for chromosome motion. Proc Natl Acad Sci U S A. 2008;105(40):15423-8.
11. Kotova YN, Ataullakhanov FI, Panteleev MA. Coated platelets formation is regulated by the dense granule secretion of ADP acting via the P2Y12 receptor. J Thromb Haemost. 2008;6:1603–5.
12. Grishchuk EL, Spiridonov IS, Volkov VA, Efremov A, Westermann S, Drubin D, Barnes G, Ataullakhanov FI, McIntosh JR. Different assemblies of the DAM1 complex follow shortening microtubules by distinct mechanisms. Proc Natl Acad Sci U S A. 2008;105(19):6918-23.
13. Korendyaseva TK, Kuvatov DN, Volkov VA, Martinov MV, Vitvitsky VM, Banerjee R, Ataullakhanov FI. An allosteric mechanism for switching between parallel tracks in mammalian sulfur metabolism. PLoS Comput Biol. 2008;4(5):e1000076.
14. Efremov A, Grishchuk EL, McIntosh JR, Ataullakhanov FI. In search of an optimal ring to couple microtubule depolymerization to processive chromosome motions. Proc Natl Acad Sci U S A. 2007;104(48):19017-22.
15. Schwartz CL, Sarbash VI, Ataullakhanov FI, McIntosh JR, Nicastro D. Cryo-fluorescence microscopy facilitates correlations between light and cryo-electron microscopy and reduces the rate of photobleaching. J Microsc. 2007;227(Pt 2):98-109.
16. Panteleev MA, Ananyeva NM, Ataullakhanov FI, Saenko EL. Mathematical models of blood coagulation and platelet adhesion: clinical applications. Curr Pharm Des. 2007;13(14):1457-67.
17. Skorokhod O, Kulikova EV, Galkina NM, Medvedev PV, Zybunova EE, Vitvitsky VM, Pivnik AV, Ataullakhanov FI. Doxorubicin pharmacokinetics in lymphoma patients treated with doxorubicin-loaded eythrocytes. Haematologica. 2007;92(4):570-1.
18. Sinauridze EI, Kireev DA, Popenko NY, Pichugin AV, Panteleev MA, Krymskaya OV, Ataullakhanov FI. Platelet microparticle membranes have 50- to 100-fold higher specific procoagulant activity than activated platelets. Thromb Haemost. 2007;97(3):425-34.
19. Pokhilko AV, Ataullakhanov FI, Holmuhamedov EL. Mathematical model of mitochondrial ionic homeostasis: three modes of Ca2+ transport. J Theor Biol. 2006;243(1):152-69.
20. Panteleev MA, Ovanesov MV, Kireev DA, Shibeko AM, Sinauridze EI, Ananyeva NM, Butylin AA, Saenko EL, Ataullakhanov FI. Spatial propagation and localization of blood coagulation are regulated by intrinsic and protein C pathways, respectively. Biophys J. 2006;90(5):1489-500.
21. Panteleev MA, Ananyeva NM, Greco NJ, Ataullakhanov FI, Saenko EL. Factor VIIIa regulates substrate delivery to the intrinsic factor X-activating complex. FEBS J. 2006;273(2):374-87.
22. Ataullakhanov FI, Panteleev MA. Mathematical modeling and computer simulation in blood coagulation. Pathophysiol Haemost Thromb. 2005;34(2-3):60-70.
23. Ataullakhanov FI, Panteleev MA. Towards virtual coagulation. Pathophysiol Haemost Thromb. 2005;34(2-3):58-9.
24. Hemker HC, Ataullakhanov FI. Good mathematical practice: simulation of the hemostatic-thrombotic mechanism, a powerful tool but one that must be used with circumspection. Pathophysiol Haemost Thromb. 2005;34(2-3):55-7.
25. Panteleev MA, Ananyeva NM, Greco NJ, Ataullakhanov FI, Saenko EL. Two subpopulations of thrombin-activated platelets differ in their binding of the components of the intrinsic factor X-activating complex. J Thromb Haemost. 2005;3(11):2545-53.
26. Prudova A, Martinov MV, Vitvitsky VM, Ataullakhanov FI, Banerjee R. Analysis of pathological defects in methionine metabolism using a simple mathematical model. Biochim Biophys Acta. 2005;1741(3):331-8.
27. Molodtsov MI, Grishchuk EL, Efremov AK, McIntosh JR, Ataullakhanov FI. Force production by depolymerizing microtubules: a theoretical study. Proc Natl Acad Sci U S A. 2005;102(12):4353-8.
28. Molodtsov MI, Ermakova EA, Shnol EE, Grishchuk EL, McIntosh JR, Ataullakhanov FI. A molecular-mechanical model of the microtubule. Biophys J. 2005;88(5):3167-79.
29. Ovanesov MV, Ananyeva NM, Panteleev MA, Ataullakhanov FI, Saenko EL. Initiation and propagation of coagulation from tissue factor-bearing cell monolayers to plasma: initiator cells do not regulate spatial growth rate. J Thromb Haemost. 2005;3(2):321-31.
30. Grishchuk EL, Molodtsov MI, Ataullakhanov FI, McIntosh JR. Force production by disassembling microtubules. Nature. 2005;438(7066):384-8.

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